Publications

Modeling resistance to the broadly neutralizing antibody PGT121 in people living with HIV-1

Cassidy T, Stephenson KE, Barouch DH, Perelson AS.

PLoS Comput Biol. 2024 Mar 29;20(3):e1011518. doi: 10.1371/journal.pcbi.1011518. eCollection 2024 Mar.

Molecular Determinants of PQBP1 Binding to the HIV-1 Capsid Lattice

Piacentini J, Allen DS, Ganser-Pornillos BK, Chanda SK, Yoh SM, Pornillos O.

J Mol Biol. 2024 Feb 15;436(4):168409. doi: 10.1016/j.jmb.2023.168409. Epub 2023 Dec 20.

Breaking the Silence: Regulation of HIV Transcription and Latency on the Road to a Cure

Natasha N Duggan NN, Dragic T, Chanda SK, Pache L

Viruses. 2023 Dec 15;15(12):2435.

CD8(+) T cells control SIV infection using both cytolytic effects and non-cytolytic suppression of virus production

Policicchio BB, Cardozo-Ojeda EF, Xu C, Ma D, He T, Raehtz KD, Sivanandham R, Kleinman AJ, Perelson AS, Apetrei C, Pandrea I, Ribeiro RM.

Nat Commun. 2023 Oct 20;14(1):6657. doi: 10.1038/s41467-023-42435-8.

Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir

Kumar MR, Fray EJ, Bender AM, Zitzmann C, Ribeiro RM, Perelson AS, Barouch DH, Siliciano JD, Siliciano RF.

Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2313209120. doi: 10.1073/pnas.2313209120. Epub 2023 Oct 16.

Regulation of Immune Homeostasis, Inflammation, and HIV Persistence by the Microbiome, Short-Chain Fatty Acids, and Bile Acids

Enriquez AB, Ten Caten F, Ghneim K, Sekaly RP, Sharma AA.

Annu Rev Virol. 2023 Sep 29;10(1):397-422. doi: 10.1146/annurev-virology-040323-082822.

T cell activation is insufficient to drive SIV disease progression

Apetrei C, Gaufin T, Brocca-Cofano E, Sivanandham R, Sette P, He T, Sivanandham S, Martinez Sosa N, Martin KJ, Raehtz KD, Kleinman AJ, Valentine A, Krampe N, Gautam R, Lackner AA, Landay AL, Ribeiro RM, Pandrea I.

JCI Insight. 2023 Jul 24;8(14):e161111. doi: 10.1172/jci.insight.161111.

The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy

McMyn NF, Varriale J, Fray EJ, Zitzmann C, MacLeod H, Lai J, Singhal A, Moskovljevic M, Garcia MA, Lopez BM, Hariharan V, Rhodehouse K, Lynn K, Tebas P, Mounzer K, Montaner LJ, Benko E, Kovacs C, Hoh R, Simonetti FR, Laird GM, Deeks SG, Ribeiro RM, Perelson AS, Siliciano RF, Siliciano JM.

J Clin Invest. 2023 Sep 1;133(17):e171554. doi: 10.1172/JCI171554.

Opportunities for CAR-T Cell Immunotherapy in HIV Cure

Campos-Gonzalez G, Martinez-Picado J, Velasco-Hernandez T, Salgado M.

Viruses. 2023 Mar 19;15(3):789. doi: 10.3390/v15030789.

Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants

Fray EJ, Wu F, Simonetti FR, Zitzmann C, Sambaturu N, Molina-Paris C, Bender AM, Liu PT, Ventura JD, Wiseman RW, O'Connor DH, Geleziunas R, Leitner T, Ribeiro RM, Perelson AS, Barouch DH, Siliciano JD, Siliciano RF.

Cell Host Microbe. 2023 Mar 8;31(3):356-372.e5